From the Lancet:

Background
Cell therapy for large burns is dependent upon autologous epidermis reconstructed in vitro. However, the effectiveness of current procedures is limited by the delay needed to culture the patient’s own keratinocytes. To assess whether the keratinocyte progeny of human embryonic stem cells (hESCs) could be used to form a temporary skin substitute for use in patients awaiting autologous grafts, we investigated the cells’ capability of constructing a pluristratified epidermis.
Methods
hESCs from lines H9 and SA01 were seeded at least in triplicate on fibroblast feeder cells for 40 days in a medium supplemented with bone morphogenetic protein 4 and ascorbic acid. Molecular characterisation of cell differentiation was done throughout the process by quantitative PCR, fluorescence-activated cell sorting, and immunocytochemical techniques. Keratinocyte molecular differentiation and functional capacity to construct a human epidermis were assessed in vitro and in vivo.

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Blind and nearly hairless, naked mole rats may help scientists develop better treatment methods for brain injuries.

Blind, nearly hairless, and looking something like toothy, plump, pink fingers, naked mole rats may rank among nature’s most maligned creatures, but their unusual physiology endears them to scientists.

Two University of Illinois at Chicago researchers report in the Dec. 9 issue of NeuroReport (now on-line) that adult naked mole rat brain tissue can withstand extreme hypoxia, or oxygen deprivation, for periods exceeding a half-hour — much longer than brain tissue from other mammals.

The findings may yield clues for better treatment of brain injuries associated with heart attack, stroke and accidents where the brain is starved of vital oxygen.

John Larson, associate professor of physiology in psychiatry, and Thomas Park, professor of biological sciences, studied African naked mole rats — small rodents that live about six feet underground in big colonies of up to 300 members. The living is tight and the breathing even worse, with the limited air supply high in carbon dioxide and low in oxygen.

More details on the research is available from PhysOrg.

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He points out that biologists have long known that photons play a central role in the biochemistry of many plant and bacterial cells. The basic idea, laid out in the 1960s, is that optical or UV photons enter a cell and stimulate the creation of excitons, electron-hole pairs, on certain long chain molecules. The exciton travels along the molecule, influencing the way it reacts with other species within the cell. This is the basic theory behind photosynthesis.

Mayburov’s idea is that this process is, first, reversible, second, not limited to photosynthetic cells and third, possible to modulate for communication.

You can read more on the research from Technology Review.

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The key is a novel polymer laced with an intricate network of nano-sized tunnels that can be filled with dyes. Initial studies have shown that the technology performs faster than the transition sunglasses on the market today, says Jackie Ying, director of the Institute for Bioengineering and Nanotechnology (IBN) in Singapore, and developer of the lenses. The research is part of a broader effort at IBN to develop new materials for contact lenses that can dispense drugs and diagnose diseases.

Read more on the research from the Technology Review.

Todd Kuiken and colleagues at the Rehabilitation Institute of Chicago first reported the technique in a single patient in 2007, and now they have tested it in several other patients. The patients could all successfully control the advanced prosthetic, which features motorized shoulders, elbows, wrists and hands. They could move the arm in space, mimic hand motions, and pick up a varietyt of objects, including a water glass, a delicate cracker, and a checker rolling across a table.

The motorized arm prostheses most commonly used today co-opt existing shoulder movements to control the hand, elbow or wrist on the limb. These devices can be frustrating and slow: the user must consciously contract those muscles to trigger a movement, and only one movement can be performed at a time.

Kuiken has developed an entirely new kind of interface. Using a surgical procedure called targeted muscle reinnervation, surgeons transfer nerves that previously carried signals to the amputated limb to muscles in the chest and upper arm. The rerouted nerves then grow into the muscles, which contract when the patient thinks about moving the lost limb. Those signals are read by sensors on the prosthetic limb and translated into movement.

More information is available from Technology Review.

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Dubbed the Health Information Technology for Economic and Clinical Health Act (HITECH), the plan would encourage doctors and hospitals to use electronic record-keeping and ordering systems by providing $18 million in incentives through Medicare and Medicaid reimbursements. Starting in 2011, physicians who show that they are “meaningfully” using health IT would be eligible for $40,000 to $65,000, and hospitals would be eligible for several million dollars. The incentives would be phased out over time, with penalties in place by 2016.

The bill allocates $2 billion over the next two years for planning and training, including ensuring that new programs adhere to specific interoperability standards. That will be crucial in making certain that data can be transferred between different medical centers and physicians, and that doctors are schooled in how to incorporate electronic record keeping and other technologies into their practices. It would also strengthen privacy and security laws to protect the growing amount of personal medical information that will become electronic.

More information available from the Technology Review.

The research shows that carbon nanotubes, which, like neurons, are highly electrically conductive, form extremely tight contacts with neuronal cell membranes. Unlike the metal electrodes that are currently used in research and clinical applications, the nanotubes can create shortcuts between the distal and proximal compartments of the neuron, resulting in enhanced neuronal excitability.

The study was conducted in the Laboratory of Neural Microcircuitry at EPFL in Switzerland and led by Michele Giugliano (now an assistant professor at the University of Antwerp), University of Trieste professor Laura Ballerini and Maurizio Prato, also from the University of Trieste. “This result is extremely relevant for the emerging field of neuro-engineering and neuroprosthetics,” explains Giugliano, who hypothesizes that the nanotubes could be used as a new building block of novel “electrical bypass” systems for treating traumatic injury of the central nervous system. Carbon nano-electrodes could also be used to replace metal parts in clinical applications such as deep brain stimulation for the treatment of Parkinson’s disease or severe depression. And they show promise as a whole new class of “smart” materials for use in a wide range of potential neuroprosthetic applications.

Source: http://actualites.epfl.ch/presseinfo-com?id=693&newlang=eng

Transplanted stem cells have previously shown promise in reversing brain damage caused by strokes, as well as by neurological diseases like Parkinson’s, Alzheimer’s, and Huntington’s. But their use in treating birth defects is relatively new. In recent years, a handful of research teams have been developing stem-cell-based therapies for rodents with real or simulated birth defects in the brain.

More on this research at Technology Review.

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